Payne-less – Patented micronised PEA 60s

Palmitoylethanolamide (PEA) is a fatty acid amide that naturally occurs in the body as part of the endocannabinoid family, a group of fatty acid derivatives that play a crucial role in the biological regulation of inflammation and pain.

The mechanism of action, as discovered by Nobel prize winner Professor Rita Levi Montalcini, is completely different from standard anti-inflammatories or pain medicines.

In the 1990s, Levi-Montalcini and her team discovered that PEA , a naturally occurring lipid molecule, played a significant role in modulating pain and inflammation.

They proposed the mechanism of Autacoid Local Inflammation Antagonism (ALIA), where PEA acts as an autacoid (a local modulating molecule) that counteracts inflammation and pain in the vicinity of its production. PEA was found to inhibit the release of pro-inflammatory molecules from mast cells, a type of white blood cell involved in inflammatory responses.

Mechanism of action:

Local Accumulation: Once ingested and absorbed into the bloodstream, PEA can circulate throughout the body.

However, it preferentially accumulates in cells and tissues undergoing stress, inflammation, or pain. This targeted accumulation is partly due to the increased expression of receptors and binding sites in these areas, which PEA can bind to or modulate.

Cellular Mechanisms of Action: PEA modulates various cellular mechanisms involved in inflammation and pain. For example, it inhibits the release of pro-inflammatory mediators and acts on mast cells, which are key players in the inflammatory process. These cells are more active and numerous in areas of pain and inflammation, allowing PEA to act more effectively where it’s needed.

Autacoid Local Pain Management: As an autacoid, PEA enhances the body’s innate repair mechanisms in response to pain and inflammation. Autacoids are local hormones that have a short-range effect. PEA’s role as an autacoid means it naturally seeks out and modulates local cellular environments, contributing to its ability to target areas of pain and inflammation after systemic administration.

Feedback Mechanisms: The body’s natural feedback mechanisms also play a role. In areas of pain and inflammation, the expression of enzymes and receptors that metabolize or interact with PEA may change, facilitating its localized action. This means that PEA can be more active or less rapidly degraded in areas where it is most needed, enhancing its local effects.

In summary, PEA’s ability to act locally on pain and inflammation, even when taken orally, is attributed to its mechanisms of action at the cellular level, preferential accumulation in inflamed or damaged tissues, and the body’s natural regulatory systems that modulate its activity based on the local environment.

Implications of the ALIA Mechanism
Local Modulation: The ALIA mechanism suggests that PEA acts locally at the site of inflammation or tissue damage to modulate pain and inflammatory responses. This localized action helps in targeting the inflammation without affecting other parts of the body, reducing the potential for side effects.

This is a revolutionary discovery of reducing inflammation, as discovered by Nobel prize winner Professor Rita Levi Montalcini.

What’s in the box
1x bottle of Payne-less 60 capsules

Disclaimer
DISCLAIMER: This product may be a complementary medicine and/or not have been evaluated and verified by the South African Health Products Regulatory Authority for its quality, safety or intended use. Use of this product is therefore not intended to compensate for diagnosis, treatment, cure, or mitigation of medical conditions and must not substitute the obtaining of medical advice from a registered health professional for any health or health-related conditions.